Abstract:Atherosclerosis（AS）is a chronic inflammatory vascular disease characterized by progressive plaque accumulation in the walls of large and medium-sized arteries. This process involves damage to endothelial cells，smooth muscle cells and macrophages， which play key roles in the initiation and progression of AS as well as the increase in plaque vulnerability. Cell death mechanisms such as autophagy，pyroptosis and ferroptosis are important in revealing the molecular mechanisms of AS， and these mechanisms are significantly different from other cell death modes in morphology，biochemistry and genetics. This review summarizes the current research progress to analyze the crosstalk between these cell death mechanisms， in particular how they collectively affect the pathological course of AS and plaque stability. It is expected to provide new insights into the mechanism and treatment of AS.