Abstract:Systemic lupus erythematosus (SLE) is an autoimmune disease, which can involve multiple organs. Currently, the involvement of the respiratory system in SLE has not received the same attention as skin, joint and kidney injuries, but it has a high incidence rate, complex clinical manifestations and lack specificity, making it prone to missed diagnosis or misdiagnosis. Moreover, its pathogenic mechanism has not yet been fully elucidated, and clinical treatment still primarily relies on empirical immunosuppression, with some patients showing poor efficacy. Therefore, an in-depth exploration of the pathophysiological mechanism of lung injury in SLE, the search for biomarkers of early diagnosis, and optimization of individualized treatment strategies are of great significance for improving the quality of life and long-term prognosis of patients.