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投稿时间：2025-10-09 网络发布日期：2026-04-02
投稿时间：2025-10-09 网络发布日期：2026-04-02
中文摘要: 目的探究清热养阴汤联合二甲双胍对血糖控制不佳的2型糖尿病（T2DM）患者稳态模型评估胰岛β细胞功能指数（HOMA-β）及血糖达标率的改善情况。方法纳入2022年1月至2025年2月厦门长庚医院收治的124例已接受3个月以上降糖治疗但控制效果不佳的［糖化血红蛋白（HbA1c）>7%］的T2DM患者，随机分为两组，每组各62例。对照组在原有治疗方案上加用二甲双胍片，观察组在对照组用药基础上联合清热养阴汤。两组患者均持续干预12周，比较治疗后两组患者的血糖指标、胰岛功能指标、身体质量指数（BMI）、36项健康调查简表（SF-36）评分以及不良反应的发生情况。结果治疗后两组空腹血糖（FPG）、HbA1c、餐后2 h血糖（2hPG）、稳态模型评估胰岛素抵抗指数（HOMA-IR）、BMI均下降（P<0.05），HOMA-β、SF-36评分升高（P<0.05），且治疗后以上指标观察组均优于对照组（P<0.05）。与对照组相比，观察组的FPG达标率［62.90% vs 37.10%，χ2=8.258，P=0.004］、HbA1c［70.97% vs 40.32%，χ2=11.795，P=0.001］、2hPG达标率［77.42% vs 43.55%，χ2=14.880，P<0.001］达标率更高。两组治疗期间均有患者出现低血糖、头痛、腹痛、恶心现象，且观察组和对照组的不良反应总发生率相近［9.68% vs 12.90%，χ2=0.322，P=0.570］。结论清热养阴汤联合二甲双胍治疗方案可显著提升T2DM患者血糖控制水平、缓解胰岛素抵抗、改善生活质量，且具有安全性。
Abstract:Objective To explore the effect of Qingre Yangyin Decoction combined with metformin on the improvement of islet β cell function index and the rate of blood glucose reaching the standard in type 2 diabetes mellitus (T2DM) patients with poor blood glucose control. Methods A total of 124 T2DM patients, who were admitted to Xiamen Chang Gung Hospital between January 2022 and February 2025 and had received hypoglycemic treatment for over three months with inadequate control [glycated hemoglobin (HbA1c) >7%], were included and divided into two groups randomly, with 62 cases in each group. The control group received metformin tablets in addition to the original treatment plan, while the observation group received a combination of Qingre Yangyin Decoction on the basis of the control group’s medication. Both groups of patients received continuous intervention for 3 months, and their blood glucose indicators, islet function indicators, body mass index (BMI), 36-Item Short Form Health Survey (SF-36) score, and incidence of adverse reactions were compared after treatment. Results After treatment, the fasting blood glucose (FPG), HbA1c, 2-hour postprandial blood glucose (2hPG), homeostasis model assessment of insulin resistance (HOMA- IR), and BMI of both groups decreased (P<0.05), while HOMA-β and quality of life scores increased (P<0.05). Moreover, after treatment, the observation group showed better results in these indicators than the control group (P<0.05). Compared with the control group, the observation group had a higher compliance rate for FPG (62.90% vs 37.10%, χ2= 8.258, P=0.004), HbA1c (70.97% vs 40.32%, χ2=11.795, P=0.001), and 2hPG (77.42% vs 43.55%, χ2=14.880, P< 0.001). During the treatment period, both groups of patients experienced hypoglycemia, headache, abdominal pain, and nausea, and the overall incidence of adverse reactions was similar between the observation group and the control group (9.68% vs 12.90%, χ2=0.322, P=0.570). Conclusion The combination therapy of Qingre Yangyin Decoction and metformin can significantly improve the glycemic level, alleviate insulin resistance, improve quality of life in T2DM patients, and is safe.
keywords: Qingre Yangyin Decoction Metformin Poor glycemic control Type 2 diabetes mellitus Consumptive thirst Pancreatic beta cells Insulin resistance
文章编号： 中图分类号：R587.1 R255.4 文献标志码：A
基金项目:
附件
| 作者 | 单位 |
| 黄显华 | 河南中医药大学中医学院, 河南 郑州 450000 |
| 张雅婷 | 厦门长庚医院中医科, 福建 厦门 361000 |
| 黄玉妹 | 马来西亚中医总会, 马来西亚 吉隆坡 50150 |
| 许二平 | 河南中医药大学中医学院, 河南 郑州 450000 |
引用文本：
黄显华,张雅婷,黄玉妹,等.清热养阴汤联合二甲双胍治疗血糖控制不佳的2型糖尿病[J].中国临床研究,2026,39(3):463-466.
黄显华,张雅婷,黄玉妹,等.清热养阴汤联合二甲双胍治疗血糖控制不佳的2型糖尿病[J].中国临床研究,2026,39(3):463-466.