本文已被：浏览 145次 下载 139次
投稿时间：2025-06-07 网络发布日期：2026-01-27
投稿时间：2025-06-07 网络发布日期：2026-01-27
中文摘要: 目的 探讨微波消融联合吉西他滨+顺铂（GP）化疗在非小细胞肺癌（NSCLC）治疗中的疗效，并观察患者 血清中胰岛素样生长因子?1（IGF?1）、胰岛素样生长因子结合蛋白?7（IGFBP?7）、高迁移率族蛋白A2（HMGA2）及 高迁移率族蛋白B1（HMGB1）的水平变化。方法 回顾性纳入2020年6月至2023年6月沧州市人民医院内科 收集的82例周围型NSCLC患者。接受微波消融联合GP化疗为试验组，接受GP化疗为对照组。通过CT检查评 估治疗效果，使用EORTC QLQ?C30量表评估生活质量，并测定血清中IGF?1、IGFBP?7、HMGA2及HMGB1的浓 度。记录并比较两组患者的不良反应情况。结果 试验组缓解率高于对照组（65.85% vs 24.39%，P<0.05）。试 验组的总生存率和无进展生存期在1、4个月时均高于对照组（P<0.05）。治疗后试验组的生活质量明显优于对 照组（P<0.05）。试验组患者的IGF?1、HMGA2及HMGB1水平均低于对照组（P<0.05）。两组患者均出现了Ⅰ~Ⅲ 级的不良反应，但未观察到Ⅳ级不良反应的发生，两组不良反应发生率差异无统计学意义（P>0.05）。结论 微 波消融联合GP化疗在NSCLC治疗中显示出良好的疗效和安全性，能够显著提高患者的生存率和生活质量，同 时降低肿瘤细胞迁移因子水平。
Abstract:Objective To explore the efficacy of microwave ablation combined with gemcitabine + cisplatin（GP）chemotherapy in the treatment of non?small cell lung cancer（NSCLC），and to observe the changes in the serum levels of insulin?like growth factor?1（IGF?1），insulin?like growth factor binding protein?7（IGFBP?7），high mobility group protein A2（HMGA2），and high mobility group protein B1（HMGB1）in patients. Methods A retrospective study was conducted on 82 cases of peripheral NSCLC patients collected from the Department of Internal Medicine at Cangzhou People's Hospital between June 2020 and June 2023.A retrospective analysis was conducted on 82 patients with peripheral NSCLC collected from the Department of Internal Medicine of Cangzhou People's Hospital from June 2020 to June 2023. Patients who received microwave ablation combined with GP chemotherapy were assigned to the experimental group，while those who received GP chemotherapy alone were assigned to the control group. The therapeutic effect was evaluated by computed tomography examination，the quality of life was assessed using the EORTC QLQ-C30 scale，and the serum concentrations of IGF-1，IGFBP-7，HMGA2，and HMGB1 were measured.The adverse reactions of patients in the two groups were recorded and compared. Results The response rate of the experimental group was higher than that of the control group（65.85% vs 24.39%，P<0.05）. The overall survival and progression?free survival in the experimental group at 1 and 4 months were higher than those of the control group（P<0.05）. After treatment，the quality of life of the experimental group was significantly better than that of the control group（P<0.05）. The serum levels of IGFBP- 7，IGF-1，HMGA2，and HMGB1 in the experimental group were lower than those in the control group（P<0.05）. Both groups had grade Ⅰ?Ⅲ adverse reactions，but no grade Ⅳ adverse reactions were observed，and there was no statistically significant difference in the incidence of adverse reactions between the two groups（P>0.05）. Conclusion Microwave ablation combined with GP chemotherapy shows good efficacy and safety in the treatment of NSCLC. It can significantly improve the survival rate and quality of life of patients，while reducing the levels of tumor cell migration factors.
keywords: Non- small cell lung cancer Microwave ablation Gemcitabine Cisplatin Insulin-like growth factor-1 Insulin⁃like growth factor binding protein⁃7 High mobility group protein A2 High mobility group protein B1
文章编号： 中图分类号：R541.7 文献标志码：A
基金项目:河北省医学科学研究课题计划资助（20251493）
附件
| 作者 | 单位 |
| 陈晓琳 | 1. 沧州市人民医院内科, 河北 沧州 06100 |
| 宋健 | 2. 沧州市人民医院呼吸与危重症医学科, 河北 沧州 061000 |
| 刘海燕 | 2. 沧州市人民医院呼吸与危重症医学科, 河北 沧州 061000 |
| 宋苗苗 | 2. 沧州市人民医院呼吸与危重症医学科, 河北 沧州 061000 |
| 王晖 | 2. 沧州市人民医院呼吸与危重症医学科, 河北 沧州 061000 |
| Author Name | Affiliation |
| CHEN Xiaolin*，SONG Jian，LIU Haiyan，SONG Miaomiao，WANG Hui | Internal Medicine,Cangzhou People's Hospital,Cangzhou,Hebei 061000,China |
引用文本：
陈晓琳,宋健,刘海燕,等.微波消融与吉西他滨+顺铂化疗对非小细胞肺癌疗效的影响[J].中国临床研究,2026,39(1):132-137.
陈晓琳,宋健,刘海燕,等.微波消融与吉西他滨+顺铂化疗对非小细胞肺癌疗效的影响[J].中国临床研究,2026,39(1):132-137.