Abstract:Objective To investigate the therapeutic effect of Suhexiang Pill combined with conventional therapy in the treatment of disorders of consciousness in patients during the recovery phase of cerebral infarction. Methods A total of168 patients in the recovery phase of cerebral infarction，treated at Zhangjiakou Chinese Medicine Hospital between February 2023 and January 2024，were selected as research subjects. They were randomly and evenly divided into a control group and an observation group，with 84 patients in each group. During a 4- week intervention period，the control group received conventional therapy，while the observation group was given Suhexiang Pill in addition to the conventional treatment. After the treatment period，continued observation was conducted for 90 days. Clinical efficacy and neurological function were assessed using the following scales：National Institutes of Health Stroke Scale（NIHSS），Glasgow Coma Scale（GCS），Barthel Index（BI），Short Version of the Stroke Specific Quality of Life Scale（SV?SS?QoL），and Patient Health Questionnaire-9（PHQ-9）. Laboratory indicators such as triglyceride-glucose（TyG）index，total cholesterol（TC），and interleukin?6（IL?6），as well as the incidence of adverse reactions，were compared between the two groups. Kaplan-Meier survival curves for the recovery time of consciousness disorders were plotted. Results The observation group showed significantly better clinical efficacy than the control group （Z=2.640，P=0.008）. After treatment，NIHSS scores，PHQ- 9 scores，TyG，TC，and IL- 6 levels were all reduced in both groups，with the observation group showing significantly lower values compared to the control group（P<0.05）. GCS，BI，and SV- SS-QoL scores increased after treatment（P<0.05），with the observation group showing more pronounced improvements（P<0.05）. There was no significant difference in total incidence of adverse events between the observation group and control group （2.38% vs 4.76% ，χ2=0.691，P=0.406）. Survival analysis revealed that the median recovery time for consciousness disorders in the observation group was（18.00±1.34）d，significantly shorter than the control group’s（33.00±2.96）d（log?rank test：χ2=31.469，P<0.01）. Conclusion The combination of Suhexiang Pill with conventional therapy is significantly effective and safe for treating consciousness disorders in patients during the recovery phase of cerebral infarction. This approach can effectively improve patients’ neurological function and levels of consciousness，reduce levels of inflammatory markers，alleviate depressive symptoms，and enhance overall quality of life.