Abstract:Acute kidney injury（AKI），as a common clinical syndrome，is associated with high morbidity and mortality. Therefore，the prevention and early recognition of AKI is extremely important. Pannexin 1（Panx1）channel is a universally expressed，non -selective，macroporous plasma membrane channel that can effectively efflux ATP and play a key role in various physiological processes such as inflammation，energy production and cell death. The researchers found that in AKI animal models，drug inhibition or targeted knockout of Panx1 gene can play an anti -inflammatory ，reduce cell mortality ，alleviate kidney tissue damage ，and delay the occurrence and development of AKI. This article reviews the mechanism of action of Panx1 in AKI and the research progress of Panx1related drugs.