Abstract:Hypertension is a common chronic disease that poses a serious threat to human health all over the world. Its complications of heart，brain and kidney bring heavy burden to patients. The study found that the overall control rate of hypertension is less than half that of people with hypertension，and patients with refractory hypertension（RH）are more challenging due to their reduced responses to multiple antihypertensive drugs，complex clinical manifestations，special etiology，and poor prognosis and management. Obstructive sleep apnea-hypopnea syndrome（OSAHS）is an independent risk factor for RH. Its prevalence increases year by year and patients are not screened and diagnosed in time，which leads to premature occurrence of cardiovascular diseases. Renal denervation（RDN）can specifically destroy the sympathetic nerve fibers in the renal artery wall. It effectively reduce the excitability of the sympathetic nerve，reduce blood pressure，and improve ventilation in patients with RH complicated with OSAHS. This article aims to comprehensively and deeply explore the pathogenesis of RH complicated with OSAHS and the application effects of RDN in the treatment of this disease，so as to provide new theoretical support and practical solutions for solving this complicated medical problem.