Abstract:Objective To investigate the impact of internet-based comprehensive follow-up education on the treatment efficacy of patients with first-episode hyperlipidemic acute pancreatitis（HLAP）after discharge. Methods A total of 120 patients with first-episode HLAP admitted to the Department of Gastroenterology at Xuzhou Central Hospital Affiliated to Southeast University from February 2019 to February 2022 were enrolled and randomly divided into a control group and an observation group，with 60 patients in each group. The control group received only conventional treatment，while the observation group received additional internet-based comprehensive follow-up education from physicians. The serum triglyceride（TG），C-reactive protein（CRP），and interleukin-6（IL-6）levels，recurrence rate of acute pancreatitis，treatment compliance，and quality of life［Medical Outcomes Study 36-Item Short-Form Health Survey（SF-36）］were compared between the two groups.Results The SF-36 scores of the observation group at 1，3，6，and 12 months after discharge were higher than those of the control group，with statistically significant differences（P<0.05）. The complete treatment compliance rate in the observation group was higher than that in the control group（71.67% vs 43.33% ，χ²=9.855，P=0.002）. The 1-year recurrence rate in the observation group was lower than that in the control group（13.33% vs 35.00%，χ²=7.685，P=0.006）. The TG levels in the observation group at discharge and at 1，3，6，and 12 months after discharge were lower than those in the control group（P<0.05）. At 1 and 3 months after discharge，the CRP and IL-6 levels in the observation group were lower than those in the control group（P<0.05）. Conclusion Internet-based comprehensive education plays a significant role in reducing the recurrence rate and improving the quality of life inpatients with first-episode HLAP.