Abstract:Inherited arrhythmias（IA）are a group of genetic disorders involving ion channels，calcium handling proteins，and cardiomyopathic substrates，which is typically characterized by familial aggregation and a high risk of sudden death，severely disrupting the generation and conduction of cardiac electrical activity. MicroRNA（miRNA），as an endogenous short-stranded non-coding RNA，negatively regulates gene expression post - transcriptionally and plays a key role in maintaining cardiac electrophysiological homeostasis and structural integrity. miRNA expression dysregulation is closely related to the pathogenesis of IA，and once miRNA function is disrupted，it directly impairs cardiac rhythm and contractile function，thereby inducing arrhythmia.Therefore，in - depth investigation of the expression patterns and regulatory mechanisms of cardiac - specific miRNAs is of great significance for revealing the pathological mechanisms of IA and developing novel therapeutic strategies.