Abstract:Objective To observe the clinical value of the HA380 hemoperfusion combined with Xuebijing injection for patients with sepsis，and analyze the effect of this regimen on the serum levels of interleukin（IL-17 and soluble leukocyte differentiation antigen 14 subtype（Presepsin）in patients. Methods A total of 120 sepsis patients admitted to Cangzhou Central Hospital between December 2021 and June 2023 were enrolled prospectively，and randomly divided into two groups：the Xuebijing group（n=60）and the combined group（n=60）using a random number table.During the study，15 cases were excluded due to dropout，resulting in 52 cases in the Xuebijing group and 53 cases in the combined group. The Xuebijing group received intravenous Xuebijing injection，while the combined group received Xuebijing injection combined with HA380 hemoperfusion therapy. The treatment course for both groups lasted one week.The blood indicators and relevant scores of the two groups of patients before treatment and after one week of treatment，as well as the clinical efficacy and adverse reactions after one week of treatment were observed. Results After one week of treatment，the total effective rate was significantly higher in the combined group than that in the Xuebijing group （94.34% vs 80.77%，χ2=4.456，P=0.035）. Serum levels of IL- 17，tumor necrosis factor- α（TNF- α）, procalcitonin（PCT），Presepsin，serum creatinine，blood urea nitrogen，and arterial partial pressure of carbon dioxide（PaCO2），as well as Acute Physiology and Chronic Health Evaluation Ⅱ（APACHE - Ⅱ）score and Sequential Organ Failure Assessment（SOFA）score，were significantly reduced in both groups（P＜0.05），with the combined group showing significantly lower levels than the Xuebijing group（P＜0.05）. Conversely，arterial oxygen saturation（SaO2）levels and pondus hydrogenii（pH）values were significantly increased in both groups（P＜0.05），with significantly higher levels in the combined group than in the Xuebijing group（P＜0.05）. The incidence of adverse reactions was significantly lower in the combined group than in the Xuebijing group（5.66% vs 19.23%，χ2=4.456，P=0.035）. Conclusion The combination of HA380 hemoperfusion and Xuebijing has significant therapeutic effects on sepsis patients，which can improve the prognosis of patients and reduce the levels of serum IL-17 and Presepsin.