Abstract:Objective To explore the efficacy of Shaoyao Sijun Jianpi Recipe combined with Chinese medicine enema inpatients with hormone-dependent ulcerative colitis（UC）and its effect on serum D-lactic acid levels. Methods Eightypatients with hormone-dependent UC admitted to Shijiazhuang Traditional Chinese Medicine Hospital from January2020 to January 2022 were included in the study，and were randomly divided into enema group（40 cases）and combination group（40 cases）using a random number table method. The enema group was given routine treatment（prednisone，omeprazole，mesalazine）and Chinese medicine enema，and the combination group was supplemented with the hospital's self-developed Shaoyao Sijun Jianpi Recipe on the basis of enema group. After 6 weeks of continuous treatment，the clinical efficacy，serum D-lactic acid level，inflammatory factor levels［interleukin（IL）-17，tumornecrosis factor -α（TNF -α），IL -10］and Chinese medicine syndrome scores were compared between the two groups.Results The total effective rate of the combination group was higher than that of the enema group（85.00% vs 65.00%，χ2=4.267，P=0.039）. After treatment，serum IL-10 levels in both groups were higher than those before treatment，andthe combination group was higher than the enema group（P<0.05）；serum TNF-α and IL-17 levels and Chinesemedicine syndrome scores（fatigue，mucopurulent bloody stool，loose stool）in both groups were lower than those beforetreatment，and the combination group was lower than the enema group（P<0.05）. Serum D -lactic acid levels in bothgroups decreased sequentially before treatment，at 3 and 6 weeks of treatment（P<0.05），and the combination groupwas significantly lower than the enema group at 3 and 6 weeks（P<0.05）. Conclusion On the basis of conventionalWestern medicine treatment，Shaoyao Sijun Jianpi Recipe combined with Chinese medicine enema can effectivelyreduce inflammatory response，improve clinical symptoms，and decrease D-lactic acid level in patients with hormone-dependent UC，with favorable efficacy.