Abstract:The onset of ulcerative colitis（UC）is closely related to intestinal flora imbalance，with a significant decrease in the abundance of Akkermansia muciniphila being a key feature. Recent studies have found that active components of Chinese medicine can improve UC symptoms by significantly increasing the abundance of Akkermansia muciniphila，regulating short-chain fatty acid levels， enhancing the intestinal mucosal barrier，and reducing the levels of inflammatory factors. This article systematically reviews the role of Akkermansia muciniphila in the treatment of UC and the mechanism by which active components of Chinese medicine regulate Akkermansia muciniphila to improve UC，providing a new theoretical basis for the development of UC adjuvant therapies based on intestinal flora intervention.