Abstract:Renal ischemia-reperfusion injury（RIRI ）is an unavoidable risk factor during kidney transplantation ，significantly impacting patients,，survival and prognosis. Currently，there is a lack of effective treatment options. RIRI involves various forms of cell death，among which pyroptosis，a newly discovered inflammatory programmed cell death，is closely associated with the occurrence and progression of RIRI. This article primarily reviews the potential pathophysiological mechanisms of pyroptosis in RIRI ，as well as the related therapeutic drugs and potential effective inhibitors targeting key molecules in this process. The aim is to provide more treatment strategies for the prevention and management of RIRI during kidney transplantation.