Abstract:As the second largest digestive gland in the human body, the pancreas lives deep behind the peritoneum and has both exocrine and endocrine functions. Pancreatic disease is a very complex disease, including pancreatic cancer, acute and chronic pancreatitis, which has been an important disease threatening human life and health. At present, although some progress has been made in the molecular pathway and mechanism of pancreatic diseases, there are still many unknowns. The role of epithelial mesenchymal transition in pancreatic diseases is a research hotspot. Epithelial-mesenchymal transition (EMT) refers to the process in which epithelial cells gradually lose their intrinsic characteristics and functions, thus obtaining the phenotype of mesenchymal cells. EMT plays an important role in many pancreatic diseases such as pancreatic cancer, acute and chronic pancreatitis. This article reviews the molecular characteristics of EMT and its application and progress in pancreatitis and pancreatic cancer in recent years.