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Received:May 27, 2022 Published Online:February 20, 2023
Received:May 27, 2022 Published Online:February 20, 2023
中文摘要: 外泌体是细胞分泌的直径40～160 nm的双层脂质囊泡，可通过调节炎症及免疫反应参与自身免疫性疾病进展。外泌体不仅可作为疾病诊断和预后评估的生物标记物，而且可作为天然的纳米载体用于传递功能性RNA、蛋白质和合成药物，在疾病治疗方面显示出临床应用的潜力。本文综述外泌体在自身免疫性疾病中的研究进展。
Abstract:Exosomes are double-layer lipid vesicles with diameter in 40-160 nm secreted by cells, which can participate in the progression of autoimmune diseases by regulating inflammation and immune responses. Exosomes can be not only served as biomarkers for disease diagnosis and prognosis assessment, but also as natural nanocarriers for delivering functional RNA, protein and synthetic drugs, showing potential for clinical application in disease treatment. This paper reviews the research progress of exosomes in autoimmune diseases.
keywords: Exosome Autoimmune diseases Cell source Mesenchymal stem cells Rheumatoid arthritis Sjogrens syndrome Inflammatory bowel disease
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基金项目:江苏省妇幼健康科研项目（F201837）；江苏现代医院管理研究（JSY-3-2019-107）；江苏省高层次卫生人才“六个一工程”拔尖人才科研项目（LGY2019023）；江苏省博士后科研资助计划（2019K260）；中国博士后科学基金新冠肺炎疫情防控专项（2020M670066ZX）
| Author Name | Affiliation |
| LIU Xia, XU Ting, WU Min | The Third Affiliated Hospital of Soochow University， Changzhou, Jiangsu 213004， China |
| Author Name | Affiliation |
| LIU Xia, XU Ting, WU Min | The Third Affiliated Hospital of Soochow University， Changzhou, Jiangsu 213004， China |
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