Abstract:ObjectiveTo analyze the prevention and treatment status of new venous thromboembolism(VTE) patients in different departments by root cause analysis, and provide policy suggestions and data support for the clinical process management of VTE patients. Methods A total of 993 new VTE patients in Beijing Shijitan Hospital from March 2019 to March 2020 were included, and their basic conditions, risk assessment stratification, prevention and treatment measures were analyzed. Results The new VTE patients in internal medicine department and surgery department were mainly at high-risk and extremely high-risk. The elderly, tumor and operation were the top three risk factors for new VET in the patients. The patients were not ideal in dynamic risk assessment, bleeding risk assessment, specialist consultation, physical prevention, active prevention and treatment specifications etc. There were significant differences in basic hospitalization information, thrombosis risk stratification, risk factors, clinical examination and diagnosis, prevention and treatment between patients in internal medicine department and surgery department(P＜0.05, P＜0.01). Conclusion The patients with elderly, surgery, and tumor patients are still the key populations for VTE prevention and treatment. The dynamic and bleeding risk assessment in VTE should not be ignored. It is worth thinking about improving the VTE-related examination process, focusing on active prevention, improving the standardization of treatment, and implementing differential prevention and treatment management according to the characteristics of different departments.