Abstract:Colon cancer is one of the top three malignant tumors worldwide. The most common site of distant metastasis is the liver.Early detection of metachronous liver metastasis after surgery and the adoption of reasonable treatment strategies are particularly important. The clinical management of metachronous liver metastasis from colon cancer has gradually evolved from a single lesion-oriented treatment to an integrated diagnosis and treatment model that integrates multidisciplinary and multi-omics information. The established diagnosis and treatment system still faces core challenges in advancing towards“precision medicine”，including incomplete guideline details and difficulty in standardizing individualized treatment plans. This article systematically reviews the definition，diagnosis，treatment and risk factors of metachronous liver metastasis from colon cancer，aiming to provide a reference for early prediction and comprehensive management in clinical practice.