胰高血糖素样肽-1受体激动剂治疗糖尿病相关认知功能障碍的作用及机制

李宏举; 薛君

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DOI:10.13429/j.cnki.cjcr.2026.06.003

中国临床研究:2026,39(6):824-828

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胰高血糖素样肽-1受体激动剂治疗糖尿病相关认知功能障碍的作用及机制

李宏举¹, 薛君^2,3

(1.内蒙古医科大学第三附属医院，内蒙古包头 014010;2.乌兰察布市中心医院老年医学科，内蒙古乌兰察布 012000;3.内蒙古医科大学第三临床学院老年医学科，内蒙古包头 014010)

Role and mechanisms of glucagon-like peptide-1 receptor agonists in the treatment of diabetes-associated cognitive dysfunction

LI Hongju¹, XUE Jun^2,3

(1.Affiliated Hospital of Mongolia Medical College, Baotou, Inner Mongolia 014010, China;2.Geriatrics Department, Ulanqab Central Hospital, Ulanqab, Inner Mongolia 012000;3.Department of Geriatrics, Third Clinical College, Inner Mongolia Medical University, Baotou, Inner Mongolia 014010)

摘要

本文已被：浏览 151次下载 155次
投稿时间：2025-08-10 网络发布日期：2026-06-28

中文摘要: 糖尿病与认知功能障碍密切相关，长期高血糖通过氧化应激、糖基化终产物蓄积、胰岛素抵抗及神经炎症等机制损害认知功能，显著增加患者痴呆风险。胰高血糖素样肽-1受体激动剂（GLP-1RAs）作为治疗糖尿病核心药物，已被推荐用于合并肥胖、心血管疾病或慢性肾病的糖尿病患者。目前关于糖尿病患者认知功能的影响和相关机制的动物实验和临床研究越来越多，本文综述了GLP-1RAs治疗糖尿病患者认知功能障碍的可能机制，并为后续研究提出建议。

中文关键词: 胰高血糖素样肽-1受体激动剂糖尿病认知功能障碍胰岛素抵抗神经炎症肠道微生态氧化应激

Abstract:Diabetes mellitus is closely associated with cognitive dysfunction, and prolonged hyperglycemia significantly increases the risk of dementia in patients by impairing cognitive function through mechanisms such as oxidative stress, accumulation of glycosylation end products, insulin resistance, and neuroinflammation. Glucagon-like peptide- 1 receptor agonists（GLP-1RAs）, as the core therapeutic agents for diabetes mellitus, have been recommended for diabetes mellitus patients with comorbidities of obesity, cardiovascular disease or chronic kidney disease. There are an increasing number of animal experiments and clinical trials on the effects and related mechanisms of cognitive function in patients with diabetes mellitus. This article focuses on exploring the possible mechanisms of GLP-1RAsintreating cognitive dysfunction in patients with diabetes mellitus, and provides suggestions for further research.

keywords: Glucagon-likepeptide-1receptoragonists Diabetesmellitus Cognitive dysfunction Insulin resistance Neuroinflammation Gut microbiota Oxidative stress

文章编号： 中图分类号：R587.1 文献标志码：A

基金项目:内蒙古自治区自然科学基金项目（2024LHMS08073）；内蒙古医学科学院公立医院科研联合基金项目（2024GLLH1252）

附件

作者	单位
李宏举	内蒙古医科大学第三附属医院,内蒙古包头 014010
薛君	乌兰察布市中心医院老年医学科,内蒙古乌兰察布 012000 内蒙古医科大学第三临床学院老年医学科,内蒙古包头 014010

Author Name	Affiliation
LI Hongju	Affiliated Hospital of Mongolia Medical College, Baotou, Inner Mongolia 014010, China
XUE Jun	Geriatrics Department, Ulanqab Central Hospital, Ulanqab, Inner Mongolia 012000 Department of Geriatrics, Third Clinical College, Inner Mongolia Medical University, Baotou, Inner Mongolia 014010

引用文本：
李宏举,薛君.胰高血糖素样肽-1受体激动剂治疗糖尿病相关认知功能障碍的作用及机制[J].中国临床研究,2026,39(6):824-828.

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