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投稿时间：2025-07-28 网络发布日期：2026-05-01
投稿时间：2025-07-28 网络发布日期：2026-05-01
中文摘要: 目的 分析人类表皮生长因子受体2（HER-2）阳性乳腺癌患者保乳手术后复发的危险因素，探讨糖类抗原 15-3（CA15-3）、CC 趋化因子配体 20（CCL20）、自然杀伤（NK）细胞联合预测其术后复发的价值。方法 以2021年6月至2023年6月于济宁医学院附属日照市人民医院行保乳手术的HER-2阳性乳腺癌患者96例为研究对象，依据术后6个月的复发情况将其分为复发组（n=21）及未复发组（n=75）。采用单因素及多因素logistic回归分析影响 HER-2 阳性乳腺癌保乳手术后复发的危险因素，采用受试者工作特征（ROC）曲线分析 CA15-3、CCL20及NK细胞对HER-2阳性乳腺癌保乳术后复发的预测价值。结果 两组年龄、肿瘤直径、月经状态、临床分期、组织学分级、肿瘤家族史比较差异均无统计学意义（P>0.05）。复发组的腋窝淋巴结转移率、血清CA15-3、CCL20水平及NK细胞水平均高于未复发组（P<0.05）。ROC曲线分析结果显示，CA15-3、CCL20及NK细胞联合预测HER-2阳性乳腺癌保乳术后复发的曲线下面积（AUC）为0.999，灵敏度为97.33%，特异度为100.00%。联合预测的效能均优于各指标单独预测。结论 术后腋窝淋巴结转移、血清 CA15-3、CCL20 及 NK 细胞水平升高是HER-2阳性乳腺癌保乳术后复发的危险因素；CA15-3、CCL20及NK细胞对HER-2阳性乳腺癌保乳术后复发均具有一定的预测价值，三种指标联合检测可提升其预测效能。
Abstract:Objective To analyze the risk factors of recurrence of human epidermal growth factor receptor 2（HER -2）positive breast cancer patients after breast - conserving surgery，and to explore the value of carbohydrate antigen 15-3（CA15-3），CC chemokine ligand 20（CCL20），and natural killer（NK）cells in predicting postoperative recurrence.Methods A total of 96 patients with HER - 2 positive breast cancer who underwent breast - conserving surgery in Rizhao People ??s Hospital Affiliated to Jining Medical University from June 2021 to June 2023 were selected as the research subjects. According to the recurrence status 6 months after surgery，the patients were divided into recurrence group（n=21）and non-recurrence group（n=75）. Univariate and multivariate logistic regression analyses were used to identify the risk factors for recurrence of HER - 2 positive breast cancer after breast - conserving surgery. Receiver operating characteristic（ROC）curve was used to analyze the predictive value of CA15 - 3，CCL20 and NK cells for recurrence of HER-2 positive breast cancer after breast-conserving surgery. Results There were no significant differences in age，tumor diameter，menstrual status，clinical stage，histological grade and tumor family history between the two groups（P>0.05）. The axillary lymph node metastasis rate，serum CA15-3，CCL20 and NK cell levels in the recurrence group were higher than those in the non-recurrence group（P<0.05）. ROC curve analysis showed that the area under thecurve（AUC）of CA15-3，CCL20 and NK cells combined to predict the recurrence after breast -conserving surgery for HER - 2 positive breast cancer was 0.999，with a sensitivity of 97.33% and a specificity of 100.00%. The efficacy of combined prediction was better than that of individual index prediction. Conclusion Axillary lymph node metastasis，elevated serum CA15-3，CCL20 and NK cell levels are risk factors for recurrence of HER-2 positive breast cancer after breast - conserving surgery. CA15-3，CCL20 and NK cells all have certain predictive value for recurrence after breast-conserving surgery for HER - 2 positive breast cancer，and combined detection of the three indexes can improve theirpredictive efficacy.
keywords: Breast cancer,Human epidermal growth factor receptor 2 positive Breast-conserving surgery Carbohydrate antigen 15-3 CC chemokine ligand 20 Natural killer cell Breast cancer recurrence Predictive value
文章编号： 中图分类号：R737.9 文献标志码：A
基金项目:
附件
| Author Name | Affiliation |
| ZONG Shoukai，CHI Nana，GUO Xiangting，WANG Kai | Department of General Surgery,Rizhao People??s Hospital Affiliated to Jining Medical University,Rizhao,Shandong 276800,China |
引用文本：
宗守凯， 迟娜娜， 郭向婷， 王锴.CA15-3、CCL20联合NK细胞预测HER-2阳性乳腺癌保乳手术后复发的价值[J].中国临床研究,2026,39(4):543-546.
宗守凯， 迟娜娜， 郭向婷， 王锴.CA15-3、CCL20联合NK细胞预测HER-2阳性乳腺癌保乳手术后复发的价值[J].中国临床研究,2026,39(4):543-546.