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投稿时间：2025-12-12 网络发布日期：2026-05-01
投稿时间：2025-12-12 网络发布日期：2026-05-01
中文摘要: 目的 探讨毛发鼻指（趾）综合征1型（TRPS1）在非特殊型乳腺浸润性癌（IBC-NST）中的表达特征，分析其与临床病理参数及预后的相关性。方法 纳入唐山市工人医院2021年1月至2022年12月确诊的IBC-NST患者122例作为研究对象，其中61例患者同时收集距肿瘤边缘≥2 cm的癌旁正常乳腺组织作为对照。通过免疫组化EnVision二步法检测122例肿瘤组织及61例癌旁组织TRPS1蛋白的表达情况，依据免疫组化TRPS1表达评分将患者分为高表达组（≥4分）与低表达组（≤3分）。收集患者的临床病理学资料，分析TRPS1表达水平与各项临床病理特征之间的关系。对所有患者进行为期 3 年的随访，运用多因素 Cox 比例风险回归模型分析影响患者预后的独立因素。结果 TRPS1在乳腺NST组织中的阳性表达率为89.34%（109/122），显著高于癌旁组织的14.75%（9/61）（χ2=98.789，P<0.01）。TRPS1高表达组65例，低表达组57例。TRPS1高表达与较高的组织学分级（P=0.002）、TNM 分期Ⅲ期（P=0.013）、淋巴结转移（P=0.017）以及三阴性乳腺癌（TNBC）亚型（P=0.030）显著相关。多因素 Cox 回归分析显示，TNM 分期Ⅲ期（HR =3.215，95%CI ：1.642~6.298）、存在淋巴结转移（HR =2.547，95%CI ：1.358~4.813）和 TRPS1 高表达（HR =2.332，95%CI ：1.205~4.514）是影响患者 3 年随访期疾病进展的独立危险因素。结论 TRPS1在IBC-NST组织中呈高表达，其高表达与肿瘤的恶性发展进程以及不良的预后结局密切相关，可作为评估IBC-NST患者预后的潜在独立预测标志物。
Abstract:Objective To investigate the expression characteristics of trichorhinophalangeal syndrome type 1（TRPS1）in invasive breast carcinoma of no special type（IBC - NST），and to analyze its correlation with clinicopathological parameters and prognosis. Methods A total of 122 patients diagnosed with IBC-NST at Tangshan Workers?? Hospital from January 2021 to December 2022 were included as research subjects. Among them，61 patients had normal breast tissues adjacent to the tumor margin ≥2 cm were collected as controls. The expression status of TRPS1 protein in 122 tumor tissues and 61 adjacent tissues was detected using the immunohistochemical EnVision two - step method. Patients weredivided into high expression group（≥4 points）and low expression group（≤3 points）based on the expression score ofTRPS1 in immunohistochemisty. Clinical pathological data of the patients were collected simultaneously to analyze the correlation between TRPS1 expression levels and various clinical pathological characteristics. All patients were followed up for a period of 3 years，and the independent influencing factors affecting patient prognosis were explored using a multivariable Cox proportional hazards regression model. Results The positive expression rate of TRPS1 in IBC -NST tissues was 89.34%（109/122），which was significantly higher than that in adjacent non-tumor tissues（14.75%，9/61）（χ2=98.789，P<0.01）. High expression of TRPS1 was significantly correlated with higher histological grading（P=0.002），advanced TNM staging Ⅲ（P=0.013），lymph node metastasis（P=0.017），and triple - negative breast cancer（TNBC）subtype（P=0.030）. Multivariate Cox analysis revealed that TNM staging Ⅲ（HR =3.215，95%CI ：1.642- 6.298），lymphnode metastasis（HR =2.547，95%CI ：1.358-4.813），and high expression of TRPS1（HR =2.332，95%CI ：1.205-4.514）were independent risk factors for disease progression during the 3-year follow - up period. Conclusion TRPS1 exhibits high expression characteristics in IBC-NST tissues，and its high expression is closely related to the malignant progression of the tumor and poor prognostic outcomes. It can be served as a potential independent biomarker for assessing the prognosis of IBC-NST patients.
keywords: Breast cancer Invasive breast carcinoma of no special type Trichorhinophalangeal syndrome type 1 Immunohistochemistry Clinicopathological parameters Prognosis
文章编号： 中图分类号：R737.9 文献标志码：A
基金项目:河北省2024年度医学科学研究课题（20242014）
附件
| 作者 | 单位 |
| 王宝英 | 1. 华北理工大学临床医学院, 河北 唐山 063000 |
| 佟易凡 | 2. 唐山市工人医院乳腺外科, 河北 唐山 063000 |
| 王会 | 3. 华北理工大学基础医学院, 河北 唐山 063200 |
| Author Name | Affiliation |
| WANG Baoying*，TONG Yifan，WANG Hui | *Clinical Medical College,North China University of Science and Technology,Tangshan,Hebei 063000,China |
引用文本：
王宝英,佟易凡,王会.TRPS1在乳腺非特殊型浸润性癌中的表达特征及其与预后的相关性[J].中国临床研究,2026,39(4):538-542.
王宝英,佟易凡,王会.TRPS1在乳腺非特殊型浸润性癌中的表达特征及其与预后的相关性[J].中国临床研究,2026,39(4):538-542.