Abstract:Diabetic foot ulcers（DFU）are a common complication in patients with diabetes，severely impacting their quality of life and increasing the risk of amputation. While hyperglycemia，neuropathy，poor circulation，and infection are all influencing factors to the development of DFU. Among them，hyperglycemia is the most significant one，as prolonged hyperglycemia can induce neuropathy，poor circulation，and infection. Therefore，it is crucial to explore how hyperglycemia leads to DFU and the roles of neuropathy，poor circulation，and infection in this process. In recent years，researchers have conducted in-depth investigations into the pathological mechanisms，clinical diagnosis，and treatment strategies for DFU. Although significant progress has been made compared to the past，numerous challenges remain in the early identification and effective management of DFU， particularly in understanding precise pathogenesis， establishing diagnostic criteria， developing individualized treatment plans， and finding specific pharmacological therapies. In light of this，this article provides a systematic review of DFU，focusing on its pathogenesis，diagnostic Methods，and treatment options（including the integration of conventional therapies and emerging technologies），with the aim of offering valuable insights for clinical practice.