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投稿时间:2025-02-17 网络发布日期:2025-11-26
投稿时间:2025-02-17 网络发布日期:2025-11-26
中文摘要: 特发性炎性肌病(IIM)是一类以骨骼肌慢性炎症为特征的异质性自身免疫性疾病。除骨骼肌受累外,IIM还可累及皮肤、心脏、肺、关节和消化道等多个器官系统。其中,消化道受累较为少见,主要表现为吞咽困难,但在严重病例中可累及整个消化道,导致假性肠梗阻、溃疡、穿孔及出血等并发症,从而显著降低患者的生活质量并增加死亡率。因此,早期识别和管理肌炎相关的消化道症状至关重要。不同亚型的炎性肌病表现出独特的器官受累模式,且不同消化道部位的受累症状差异明显。本文综述了IIM消化道受累的临床表现、特征及预后,为优化疾病管理提供参考。
Abstract:Idiopathic inflammatory myopathy (IIM) is a heterogeneous group of autoimmune diseases characterized by chronic inflammation of skeletal muscles. In addition to muscle involvement,IIM can affect various organ systems,including the skin,heart, lungs,joints,and gastrointestinal tract(GI). GI involvement is relatively uncommon,primarily presenting as dysphagia. However,it
can extend throughout the GI tract,causing complications such as pseudo- obstruction,ulcers,perforation,and bleeding in severe
cases. These severe outcomes significantly impair patients'quality of life and increase mortality,highlighting the need for greater attention and timely management. Different subtypes of IIM demonstrate distinct patterns of organ involvement,with GI manifestations varying based on the specific region affected. This review highlights the clinical features,characteristics,and prognosis of GI involvement in IIM,aiming to provide evidence for enhancing disease management and patient care.
keywords: Idiopathic inflammatory myopathy Dermatomyositis Polymyositis Inclusion body myositis Gastrointestinal involvement Dysphagia
文章编号: 中图分类号:R593.2 R575 文献标志码:A
基金项目:
附件
| Author Name | Affiliation |
| ZHANG Ruijuan,YAN Bing | Department of Rheumatology and Immunology,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China |
引用文本:
张睿娟,严冰.炎性肌病合并消化道受累的临床特征[J].中国临床研究,2025,38(11):1776-1780.
张睿娟,严冰.炎性肌病合并消化道受累的临床特征[J].中国临床研究,2025,38(11):1776-1780.
