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投稿时间：2025-01-02 网络发布日期：2025-11-26
投稿时间：2025-01-02 网络发布日期：2025-11-26
中文摘要: 目的 探讨血清星形胶质源性蛋白s-100β、甲状腺过氧化物酶抗体（TPO-Ab）及同型半胱氨酸（Hcy）水平对精神分裂症患者认知功能损害的预测价值。方法 选择2022年1月至2024年6月菏泽市第三人民医院收治的103例精神分裂症患者为研究对象，采用简易智力状态检查量表（MMSE）评估其认知功能损害情况，根据评估结果分为认知损害组及无认知损害组，检测两组受检者血清s-100β、Hcy及TPO-Ab水平，采用logistic回归分析精神分裂症患者认知功能损害的影响因素，使用受试者工作特征（ROC）曲线分析上述指标预测精神分裂症认知损害的价值。结果 103例患者中，认知损害患者47例，无认知损害患者56例。认知损害组患者精神分裂症病程、睡眠质量得分高于无认知损害组（P<0.05）。实验室检查结果显示，认知损害组患者血清s-100β、TPO-Ab 及Hcy 水平均高于无认知损害组（P<0.05）。精神分裂症病程长（OR=1.872，95%CI：1.073~3.266）、高s-100β（OR=2.083，95%CI：1.220~3.558）、高 TPO- Ab（OR=2.000，95%CI：1.185~3.375）及高 Hcy（OR=2.186，95%CI：1.334~3.582）是影响精神分裂症患者认知功能损害的独立危险因素（P<0.05）。精神分裂症患者血清 s-100β、TPO-Ab、Hcy三者联合检测预测其认知损害的效能最高［曲线下面积（AUC）=0.839］，敏感度为93.62%，特异度为69.64%。结论 精神分裂症患者认知功能损害与其血清s-100β、TPO-Ab及Hcy水平异常增高有关，可作为
临床预测该类患者认知损害的有效指标。
中文关键词: 星形胶质源性蛋白 甲状腺过氧化物酶抗体 同型半胱氨酸 精神分裂症 认知功能损害
Abstract:Objective To explore the predictive value of serum astrocyte-derived protein s-100β，thyroid peroxidase antibody（TPO-Ab）and homocysteine（Hcy）levels for cognitive impairment in patients with schizophrenia. Methods A total of 103 patients with schizophrenia admitted to Heze Third People's Hospital from January 2022 to June 2024 were selected as the research subjects. Mini Mental State Examination Scale（MMSE）was performed to assess the cognitive impairment. The patients were divided into the impairment group and non-impairment group by the evaluation results.Measurement of serum s-100β，Hcy，and TPO-Ab levels was performed in the two groups of subjects. The influencing factors of cognitive function impairment in patients with schizophrenia were analyzed by logistic regression. The values of the above levels in predicting the cognitive impairment of schizophrenia were analyzed by receiver operating characteristic（ROC）curve. Results Among the 103 patients，47 had cognitive impairment and 56 had no cognitive impairment. The scores of schizophrenia duration and sleep quality in the cognitive impairment group were higher than those in the non-impairment group（P<0.05）. The laboratory examination results showed that the cognitive impairment group had higher serum s-100β，TPO-Ab and Hcy levels than the non-impairment group（P<0.05）. Long schizophrenia course［OR（95%CI）：1.872（1.073-3.266）］，high s-100β［OR（95%CI）：2.083（1.220-3.558）］，high TPO-Ab［OR（95%CI）：2.000（1.185-3.375）］and high Hcy［OR（95%CI）：2.186（1.334-3.582）］were independent risk factors affecting cognitive impairment in patients with schizophrenia（P<0.05）. The combined detection of s- 100β，TPO-Ab and Hcy in patients with schizophrenia had the highest predictive efficacy［area under the curve（AUC）=0.839］，with a sensitivity of 93.62% and a specificity of 69.64% . Conclusion The cognitive impairment of schizophrenia patients is related to the abnormal increase of serum s- 100β，TPO-Ab and Hcy levels，which can be used as effective indices to predict the cognitive impairment of such patients.
keywords: Astrocyte⁃derived protein Thyroid peroxidase antibody Homocysteine Schizophrenia Cognitive impairment
文章编号： 中图分类号：R749.3 文献标志码：A
基金项目:山东省中医药科技项目（2021Q122）
附件
| Author Name | Affiliation |
| LI Lijuan*，TIAN Baitong，SUN Yu，ZHANG Enlong，XU Defeng，WANG Linping | *Department of Psychiatry,Heze Third People's Hospital,Heze,Shandong 274000,China |
引用文本：
李丽娟,田佰通,孙玉,等.血清s⁃100β、TPO⁃Ab及Hcy水平与精神分裂症患者认知功能的相关性[J].中国临床研究,2025,38(11):1741-1745.
李丽娟,田佰通,孙玉,等.血清s⁃100β、TPO⁃Ab及Hcy水平与精神分裂症患者认知功能的相关性[J].中国临床研究,2025,38(11):1741-1745.