Abstract:Objective To investigate the correlation between the triglyceride glucose body mass index（TyG-BMI）and liver fat content in healthy people，providing a reference for early screening and intervention of non-alcoholic fatty liver disease（NAFLD）. Methods A total of 3 503 subjects undergoing physical examination in the health management center of the Affiliated Geriatric Hospital of Nanjing Medical University from January 2023 to May 2024 were selected.Their relevant medical history information，physical examination，serum biochemical indicators and transient elastography of the liver were collected. According to the levels of the controlled attenuation parameter（CAP），which reflected liver fat content，the cases were divided into no-，mild-，moderate-，and severe- fatty liver groups，followed by relevant statistical analysis. Results Univariate analysis of variance showed that age，height，weight，BMI，waist circumference，systolic blood pressure，diastolic blood pressure，total cholesterol，triglycerides，high - density lipoprotein cholesterol，aspartate aminotransferase，alanine aminotransferase（ALT），TyG-BMI and other factors were all statistically significant among the four groups（P<0.05）. Univariate correlation analysis showed that CAP was correlated with the above indicators，with the highest correlation coefficient observed between TyG-BMI and CAP（r=0.607，P<0.01）. Ordered regression analysis showed that TyG-BMI and ALT entered the regression equation（OR=1.030，1.029，P<0.01）. Based on the TyG-BMI，a predictive model for NAFLD was constructed，with an AUC of 0.802（95%CI：0.786-0.817），the maximum value of Youden index was 0.451，and the optimal critical value of TyG-BMI was 211.50，the corresponding sensitivity and specificity were 71.7% and 74.0%，respectively. Conclusion The formation and severity of NAFLD are closely related to many factors. TyG-BMI，as a new evaluation index，can better predict and evaluate the risk of NAFLD in healthy people.