Abstract:Sepsis is a life- threatening organ dysfunction triggered by a dysregulated host response to infection. Sepsis- induced cardiomyopathy（SICM）is an acute cardiac condition caused by sepsis，characterized by high incidence and extremely high mortality.Currently，there is a lack of specific treatment strategies，and its pathophysiological mechanisms are not fully understood. Exosomes，membrane-bound vesicles secreted by almost all living cells，can facilitate intercellular communication and influence physiological processes such as immune responses and inflammatory reactions. They are also involved in the progression of SICM，including inflammation，myocardial injury，and cardiac dysfunction. This review elaborates on the role of exosomes of different origins in SICM.In the future，in-depth research is needed to explore the molecular mechanisms by which exosomes affect the pathophysiology of SICM.