Abstract:Sepsis-associated acute kidney injury（SA-AKI）is a common critical illness in hospitalized patients，characterized by high incidence，high mortality. The pathogenesis of SA - AKI is complex，with both direct mechanisms related to infection and indirect mechanisms driven by adverse treatment outcomes in sepsis. Once a diagnosis of SA-AKI is made，it is crucial to initiate appropriate support measures in time to limit further damage to the kidney，such as anti - infective therapy，fluid resuscitation，vasopressor therapy，and renal replacement therapy. There are many scholars committed to exploring the best treatment plan. Promising strategies，including new therapeutic drugs，targeted therapy and Chinese medicine therapy，hold significant potential for mitigating both the short-and long-term consequences of SA-AKI. This article provides a review on the progress in SA-AKI treatment.