Abstract:Objective To study the efficacy and safety of ciprofol in laparoscopic myomectomy anesthesia，and provide a reference for the rational selection of anesthesia Methods in clinical laparoscopic minimally invasive surgery.Methods Eighty patients who underwent laparoscopic myomectomy at Zhongshan Hospital Affiliated to Xiamen University from May 2022 to February 2024 were retrospectively grouped according to different anesthesia regimens.Thirty-two patients who received the propofol combined anesthesia regimen were the control group，and 48 patients who received the ciprofol combined anesthesia regimen were the study group. The perioperative indicators，and stress response indicators，hemodynamic indicators，cognitive functions at different time points as well as the occurrence of perioperative adverse reactions were compared between the two groups. Results The recovery time of the study groupwas shorter than that of the control group（P<0.05），and the Steward score of 30 min after recovery was higher than that of the control group（P<0.05），but there was no significant difference in the operation time between the two groups（P>0.05）. Serum levels of adrenocorticotropic hormone（ACTH）and cortisol（Cor）gradually increased with prolongedsurgery duration in both groups（P<0.05）. ACTH and Cor levels in the study group were lower than those in the control group at 5 min after tracheal intubation（T2），immediately after extubation（T3），and at the end of operation（T4）（P<0.05）. In terms of hemodynamic indicators，the levels of peripheral capillary oxygen saturation（SpO2）at T2 and T3 in the study group were（97.05%±2.50%）and（97.80%±2.32%），respectively，which were both higher than those in the control group［（94.01%±2.11%）and（95.75%±2.40%）］（P<0.05）；the mean arterial pressure（MAP）levels in thestudy group at T2，T3，and T4 were（72.90 ± 4.58）mmHg，（71.65 ± 5.50）mmHg，and（72.60 ± 4.62）mmHg，respectively，which were lower than those of the control group［（78.50±6.21）mmHg，（76.25±5.72）mmHg，（77.50±5.25）mmHg］（P<0.05）. The postoperative mini-mental state examination（MMSE）scores of the two groups were lowerthan those before surgery（P<0.05），and the MMSE scores of the control group were lower than those of the study group1 and 3 days after surgery（P<0.05）. In addition，the incidence of perioperative adverse reactions in the study group was significantly lower than that in the control group，and the difference between two groups was statistically significant（6.25% vs 25.00%，χ2=4.220，P<0.05）. Conclusion The application of ciprofol in laparoscopic myomectomy can help shorten the postoperative recovery time and improve the recovery quality of patients，with minimal influence on the hemodynamics during anesthesia. It can also inhibit intraoperative stress response，reduce the risk of postoperative cognitive function damage，and provide high safety.