Abstract:Objective To observe the effect of propofol“bridging”30 minutes before the end of surgery to prevent postoperative nausea and vomiting （PONV）in patients undergoing gynecological laparoscopic surgery under sevoflurane anesthesia. Methods A total of 70 patients undergoing general anesthesia for elective gynecological laparoscopic surgery at the First Affiliated Hospital of Anhui Medical University from June 2022 to September 2023 were enrolled prospectively，who were randomly assigned to either sevoflurane anesthesia group（group S，n=35）or propofol“bridging”group （group P，n=35）. Standardized induction protocols were applied in both groups. After induction，anesthesia was maintained with sevoflurane and remifentanil throughout surgery in group S，while the same anesthesia was maintained in group P，but sevoflurane was withdrawn 30 minutes before the end of surgery，followed by intravenous pump infusion of propofol as a bridge until surgery concluded. The patients in both groups were monitored by bispectral index（BIS）to maintain the appropriate anesthesia depth and keep the anesthesia depth stable during the bridging period. The incidence of PONV within 24 h after surgery，the incidence of moderate-to-severe PONV and the use of rescue antiemetics during 0-8 h，>8-16 h，and >16-24 h postoperatively were recorded in the two groups.Results Compared with the group S，in the group P，the incidence of PONV was significantly reduced within 24 h after surgery（17.1% vs 42.9% ，χ²=5.51，P=0.019），the incidence of moderate - to - severe PONV and the use of rescue antiemetics were significantly decreased 0- 8 h postoperatively （P<0.05），and the inhalation time and dosage of sevoflurane were significantly reduced（P<0.05）. Conclusion Propofol“bridging”can effectively reduce the incidence of PONV within 24 h after gynecologic laparoscopic surgery under sevoflurane anesthesia，and decrease the incidence of moderate-to-severe PONV and the use of rescue antiemetics in the early postoperative period.