Abstract:N-myc downstream- regulated gene 2（NDRG2）is an oncogene closely related to cell proliferation，differentiation and apoptosis，which is mainly expressed in astrocytes in the brain. Studies have shown that NDRG2 is involved in the development and progressionof stroke，psychiatric diseases，and neurodegenerative diseases by regulating the proliferation and activation of astrocytes，inflammatory responses，glutamate excitotoxicity，and the integrity of the blood brain barrier. This article reviews the important role of astrocyte-specific expression of NDRG2 in the process of different central nervous system diseases.