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Received:December 20, 2024 Published Online:July 21, 2025
Received:December 20, 2024 Published Online:July 21, 2025
中文摘要: 目的 通过孟德尔随机化（MR）分析睡眠时长和儿童注意缺陷多动障碍（ADHD）发病风险之间的因果关系。方法 从全基因组关联研究数据库下载睡眠时长数据集（ukb-b-4424）以及ADHD数据集（ieu-a-1183），筛选出48个单核苷酸多态性（SNPs）作为工具变量（Ivs）。分别使用逆方差加权法（IVW）、加权中位数法（WME）、MR-Egger回归、加权模式和简单模式方法检验睡眠时长与ADHD患病风险之间的MR分析，以风险值（OR）评估睡眠时长与ADHD发病风险的因果关联。同时运用留一法进行敏感性分析，MR-Egger截距检验水平多效性，随机效应模型检测异质性。结果 IVW分析结果显示睡眠时长与ADHD发病风险存在负相关（OR=0.597，95%CI：0.376~0.948，P=0.028）。敏感性分析结果稳定，MR-Egger截距检验无水平多效性，随机效应模型检测不存在异质性。结论 随着睡眠时长的增加，ADHD发病风险随之减低。
Abstract:Objective To investigate the causal relationship between sleep duration and the risk of attention deficit hyperactivity disorder（ADHD）in children using Mendelian randomization（MR）. Methods Genome-wide association study（GWAS）datasets for sleep duration（ukb-b-4424）and ADHD（ieu-a-1183）were downloaded，and 48 single nucleotide polymorphisms（SNPs）were selected as instrumental variables（IVs）. The causal association between sleep duration and ADHD risk was assessed using inverse-variance weighted（IVW），weighted median estimator（WME）， MR-Egger regression，weighted mode，and simple mode methods，with odds ratio（OR）used to estimate the effect. Sensitivity analysis was conducted using the leave-one-out method，while horizontal pleiotropy was evaluated using the MR-Egger intercept test，and heterogeneity was assessed using a random-effects model.Results IVW analysis revealed a negative correlation between sleep duration and ADHD risk（ OR=0.597，95%CI：0.376-0.948，P=0.028）. Sensitivity analysis confirmed stable results，and the MR-Egger intercept test indicated no significant horizontal pleiotropy. The random-effects model showed no heterogeneity. Conclusion Increased sleep duration is associated with a reduced risk of ADHD.
keywords: Sleep duration Attention deficit hyperactivity disorder Mendelian randomization Circadian rhythms
文章编号： 中图分类号：R749.94 文献标志码：A
基金项目:黑龙江中医药大学新药研究基金（2019XY05）
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