Abstract:Short-chain fatty acids are saturated fatty acids produced by specific intestinal flora, which have various functions such as maintaining intestinal homeostasis and participating in immune regulation. In recent years, the relationship between short-chain fatty acids and inflammatory diseases has gradually become a hot topic of research. Numerous studies have shown that short-chain fatty acids are associated with the occurrence and development of sepsis, and can affect the progression and prognosis of sepsis patients by regulating the body's immune cells. This article reviews the relationship between short-chain fatty acids, immune regulation and sepsis, in order to provide reference for the prevention and treatment of sepsis.