Abstract:Ovarian cancer is one of the common gynecological tumors,and its characteristics of easy recurrence, metastasis and drug resistance make the 5-year survival rate low. The metastasis and drug resistance mechanism of ovarian cancer is an extremely complex process involving multiple steps and factors. In recent years, with the recognition of tumor microenvironment (TME), its role in regulating tumor metastasis and drug resistance has been increasingly valued. This article summarizes the role and research progress of extracellular matrix, cancer-associated fibroblasts, vascular endothelial growth factors, immune related cells and molecules, adipocytes and hypoxia-inducible factors in the regulation of metastasis and drug resistance in ovarian cancer TME through literature investigation, hoping to provide clues for the in-depth study of ovarian cancer metastasis and drug resistance mechanism, so as to provide a theoretical basis and inspiration for finding solutions to overcome drug resistance of ovarian cancer in clinical practice.