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Received:August 02, 2023 Published Online:November 20, 2023
Received:August 02, 2023 Published Online:November 20, 2023
中文摘要: 目的 探讨调神疏肝法针刺治疗偏头痛的效果。方法 回顾性选取2022年10月至2023年3月华中科技大学协和深圳医院收治的80例偏头痛患者，按治疗方法不同划分为对照组（n=38）和研究组（n=42），对照组接受氟桂利嗪治疗，研究组在对照组基础上接受调神疏肝法针刺治疗。比较两组疗效、不良反应发生率及治疗前、治疗4周后临床症状积分、血流动力学指标［大脑前动脉（ACA）、大脑中动脉（MCA）、大脑后动脉（PCA）血流速度］、血管源性活性介质［血浆降钙素基因相关肽（CGRP）、内皮素1（ET-1）］、治疗前、治疗后3个月生活质量［偏头痛特异性生活质量问卷（MSQ）］。结果 研究组总有效率高于对照组（92.86% vs 76.32%, P＜0.05）。治疗4周后，两组头痛严重程度、伴随症状、每月发作次数、每次持续时间积分，MCA、ACA、PCA血流速度，血浆CGRP、ET-1水平较治疗前下降，且研究组低于对照组（P＜0.05）。治疗后3个月，两组MSQ评分较治疗前升高，且研究组高于对照组（P＜0.05）。两组不良反应总发生率比较差异无统计学意义（P＞0.05）。结论 调神疏肝法针刺治疗偏头痛能有效缓解临床症状，改善脑部血流动力学，调节血管源性活性介质水平，改善生活质量，效果显著，且安全性高。
Abstract:Objective To investigate the effect of acupuncture treatment of migraine by the method of Tiaoshen Shugan acupuncture. Methods A retrospective study was conducted on 80 migraine patients admitted to Huazhong University of Science and Technology Union Shenzhen Hospital from October 2022 to March 2023. The patients were divided into a control group (n=38) and a research group (n=42) according to different treatment methods. The control group received flunarizine treatment, while the research group received acupuncture treatment with Tiaoshen Shugan method in addition to flunarizine. The treatment efficacy, incidence of adverse reactions, clinical symptom scores before and after 4 weeks of treatment, hemodynamics［blood flow velocity in anterior cerebral artery (ACA), middle cerebral artery (MCA), and posterior cerebral artery (PCA)］, vascular-related bioactive substances ［plasma calcitonin gene-related peptide (CGRP), endothelin-1 (ET-1)］, and quality of life ［migraine-specific quality of life questionnaire (MSQ)］ were compared between the two groups. Results The research group exhibited a higher overall effective rate compared to the control group(92.86% vs 76.32%, P＜0.05). After 4 weeks of treatment, the severity of headaches, associated symptoms, monthly attack frequency, duration of each attack, MCA, ACA, and PCA blood flow velocities, and plasma CGRP and ET-1 levels were significantly reduced compared to before treatment, and the research group showed a greater reduction compared to the control group (P＜0.05). After 3 months of treatment, both groups showed improved MSQ scores compared to before treatment, and the research group had higher scores than the control group (P＜0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P＞0.05). Conclusion Tiaoshen Shugan acupuncture treatment of migraine can effectively relieve clinical symptoms, improve cerebral hemodynamics, regulate the level of vasogenic active mediators, and improve the quality of life, with significant effects and high safety.
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基金项目:广东省中医药局科研项目（20201139）
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