Abstract:Objective To explore the effect of diet coke combined with chlorhexidine gargle in oral care of tracheal intubation patients in Neurology ICU.Methods From October 2019 to October 2022, 110 patients with tracheal intubation who were admitted to the Neurology Intensive Care Unit of Huai'an First People's Hospital were selected as the research object. The patients were randomly divided into control group and observation group (n=55, each). The control group received routine oral care (wiping with saline cotton balls). In the observation group, the diet coke combined with chlorhexidine gargle was used for negative pressure washing. The incidence of ventilator-associated pneumonia (VAP), improved Beck oral score, mechanical ventilation time, and ICU hospitalization time between two groups were compared after implementing oral care. Results After implementing oral care, the incidence of VAP in the intervention group was lower than that in the control group [9.09%（5/55） vs 32.73%(18/55), χ=9.29, P＜0.05]. Compared with the control group, the observation group had lower Beck oral score (P＜0.05), ICU hospitalization time [(7.71±0.66) d vs (12.00±0.72) d, P＜0.05], and mechanical ventilation time[(5.82±0.77) d vs (8.36±0.73) d, P＜0.05]. Conclusion Diet coke combined with chlorhexidine mouthwash under negative pressure can improve oral hygiene, reduce the incidence of VAP, and shorten the hospital stay and mechanical ventilation time in ICU.