COX-2/PGE<sub>2</sub>/EP<sub>4</sub>信号轴在结肠癌中的研究进展

郑力榕; 杜昊洋; 张瑞芬; 张海荣; 包阿如汗; 于蕾; 崔宏伟

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DOI:10.13429/j.cnki.cjcr.2023.09.012

中国临床研究英文版:2023,3(9):1338-1341,1347

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COX-2/PGE₂/EP₄信号轴在结肠癌中的研究进展

郑力榕¹, 杜昊洋¹, 张瑞芬², 张海荣², 包阿如汗¹, 于蕾², 崔宏伟³

(1. 内蒙古医科大学，内蒙古呼和浩特 010110;2. 内蒙古自治区中医院，内蒙古呼和浩特 010000;3. 北京大学肿瘤医院内蒙古医院内蒙古医科大学附属肿瘤医院，内蒙古呼和浩特 010020)

Research progress on COX-2/PGE₂/EP₄ signaling axis in colon cancer

ZHENG Lirong¹, DU Haoyang¹, ZHANG Ruifen², ZHANG Hairong², BAO Aruhan¹, YU Lei¹, CUI Hongwei³

(1.Inner Mongolia Medical University, Hohhot, Inner Mongolia 010110, China;2.Inner Mongolia Hospital of Traditional Chinese Medicine, Hohhot, Inner Mongolia 010000, China;3.Peking University Oncology Hospital Inner Mongolia Hospital Inner Mongolia Medical University Affiliated Oncology Hospital, Hohhot, Inner Mongolia 010020, China)

摘要

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Received:November 17, 2022 Published Online:September 19, 2023

中文摘要: 结肠癌患者的环氧合酶2（COX-2）表达上调以及前列腺素E2（PGE₂）产生显著增加。PGE₂作为COX-2主要生成的前列腺素，在结肠癌细胞中发挥血管生成、存活、侵袭和迁移等重要作用。EP₄受体作为PGE₂信号的重要转导体，通过各种机制的过度表达增加了结肠癌细胞的生存和发育。从COX-2开始，以PGE₂继续，到EP₄结束的途径可以促进结肠癌的扩散和生长。因此，靶向COX-2/PGE₂/EP₄轴可能是治疗结肠癌的一种有价值的治疗方法。本文概述COX-2生物学活性，以COX-2/PGE₂/EP₄作为信号轴在结肠癌中的作用机制以及靶向药物在结肠癌预防中的研究进展。

中文关键词: 环氧合酶2 前列腺素E₂ EP₄受体结肠癌阿司匹林塞来昔布

Abstract:The expression of cyclooxygenase 2 (COX-2) was up-regulated and prostaglandin E₂ (PGE₂) was significantly increased in colon cancer patients. As the main prostaglandin produced by COX-2, PGE₂ plays an important role in angiogenesis, survival, invasion and migration of colon cancer cells. The EP₄ receptor, as an important transporter of PGE₂ signaling, increases the survival and development of colon cancer cells through various mechanisms of overexpression. Signal pathway starting from COX-2, continuing with PGE₂ and ending with EP₄ can promote the spread and growth of colon cancer. Therefore, targeting the COX-2/PGE₂/EP₄ axis may be a valuable treatment method for colon cancer. This article outlines the biological activity of COX-2, the mechanism of action of COX-2/PGE₂/EP₄ as a signal axis in colon cancer, and the research progress of targeted drugs in colon cancer prevention.

keywords: Cyclooxygenase 2 Prostaglandin E₂ EP₄ receptor Colon cancer Aspirin Celecoxib

文章编号： 中图分类号：R735.25 文献标志码：A

基金项目:内蒙古自治区卫健委项目（20214152）；内蒙古自治区“草原英才”工程青年创新创业人才项目（2020-44）；内蒙古医科大学致远人才项目（善学人才ZY0202031）

引用文本：

Author Name	Affiliation
ZHENG Lirong	Inner Mongolia Medical University, Hohhot, Inner Mongolia 010110, China
DU Haoyang	Inner Mongolia Medical University, Hohhot, Inner Mongolia 010110, China
ZHANG Ruifen	Inner Mongolia Hospital of Traditional Chinese Medicine, Hohhot, Inner Mongolia 010000, China
ZHANG Hairong	Inner Mongolia Hospital of Traditional Chinese Medicine, Hohhot, Inner Mongolia 010000, China
BAO Aruhan	Inner Mongolia Medical University, Hohhot, Inner Mongolia 010110, China
YU Lei	Inner Mongolia Medical University, Hohhot, Inner Mongolia 010110, China
CUI Hongwei	Peking University Oncology Hospital Inner Mongolia Hospital Inner Mongolia Medical University Affiliated Oncology Hospital, Hohhot, Inner Mongolia 010020, China

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