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Received:November 29, 2022 Published Online:August 20, 2023
Received:November 29, 2022 Published Online:August 20, 2023
中文摘要: 目的探讨外周血中氧化三甲胺（TMAO）、血清淀粉样蛋白A（SAA）水平对慢性脑缺血（CCH）的诊断价值。方法纳入2022年2月至6月在四川省人民医院神经内科就诊的患者,根据核磁共振动脉自旋标记（ASL）检查结果分为CCH组（55例）和对照组（42例）。采用ELISA法检测两组外周血中TMAO和SAA的表达量，采用ROC曲线分析其对CCH的诊断价值。结果CCH组TMAO和SAA表达量高于对照组（47.24±8.84 vs 40.81±8.33, t=3.639,P＜0.05；14.04±2.70 vs 12.20±2.30,t=3.542,P＜0.05）。TMAO、SAA高表达,有原发性高血压病是CCH发生的独立危险因素（P＜0.05）。TMAO和SAA单独诊断CCH的ROC曲线下面积（AUC）分别为0.701（95%CI：0.594~0.809）和0.675（95%CI：0.565~0.786）,两者联合检测诊断的AUC最高,为0.765（95%CI：0.667~0.863）。结论外周血TMAO和SAA与CCH的发生有关,可作为CCH的辅助诊断指标。
Abstract:ObjectiveTo investigate the diagnostic value of trimethylamine N-Oxide （TMAO） and serum amyloid A （SAA） levels in peripheral blood of patients with chronic cerebral hypoperfusion （CCH）. MethodsThe patients attending the Department of Neurology of Sichuan Provincial People's Hospital from February 2022 to June 2022 were divided into CCH group （n=55） and control group （n=42） based on the results of magnetic resonance arterial spin labeling （ASL）. The levels of TMAO and SAA were detected by ELISA and their diagnostic value for CCH were anaylzed by ROC curve. ResultsThe levels of TMAO （47.24±8.84 vs 40.81±8.33, t=3.639, P＜0.05） and SAA （14.04±2.70 vs 12.20±2.30, t=3.542, P＜0.05） in CCH group were significantly higher than those in control group. High levels of TMAO and SAA and history of primary hypertension were independent risk factors for the occurrence of CCH （P＜0.05）. The areas under ROC curve （AUC） of TMAO and SAA for diagnosing CCH were 0.701 （95%CI: 0.594-0.809） respectively and 0.675 （95%CI: 0.565-0.786）. The combined detection of TMAO and SAA achieved the highest AUC of 0.765 （95%CI: 0.667-0.863）. ConclusionBoth TMAO and SAA are related to the occurrence of CCH and can be used as auxiliary diagnostic indicators for CCH.
keywords: Chronic cerebral hypoperfusion Trimethylamine N-Oxide Serum amyloid A Arterial spin labeling technique
文章编号： 中图分类号：R743.1 文献标志码：B
基金项目:四川省科技厅项目（2021YFS0074）；成都市科技局重大科技应用示范项目（2019-YF09-00142-SN）
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