Abstract:Objective To investigate the influencing factors of coronary slow flow(CSF) in patients with chronic coronary syndrome(CCS) through clinical analysis and bibliometric study. Methods A total of 90 CCS patients who visited Dongzhimen Hospital from September 2021 to July 2022 were consecutively selected and divided into CSF group(n=37) and the normal coronary artery group(control group, n=40) according to the inclusion and exclusion criteria. The correlation between general clinical data and CSF in two groups was compared. Taking Web of Science as the literature source, the related research on CSF from 2002 to 2022 was searched. Citespace and Vosviewer software were used to carry out co-occurrence, clustering and Burst analysis with keywords as nodes, and the corresponding visual map was drawn and analyzed. Results Multivariable logistic regression analysis after univariate analysis showed that elevated hemoglobin(HGB, OR=1.103, P=0.001), atrial fibrillation(OR=19.791, P=0.010) and family history of coronary heart disease(OR=3.811, P=0.046) were the independent factors for the occurrence of CSF in CCS patients. A total of 1367 CSF-related articles were included in the bibliometric study. Keyword co-occurrence and cluster analysis showed that CSF-related disease hotspots mainly focused on angina pectoris, myocardial infarction, percutaneous coronary intervention and arterial disease. The research hotspots in imaging focused on intravascular ultrasound, thrombolysis in myocardial infarction(TIMI) blood flow measurements and angiography. The mechanism research mainly focused on atherosclerosis, endothelial dysfunction and inflammation. In the past five years, CSF-related research hotspots have focused on clinical management and prognosis. Conclusion The independent risk factors of CSF in CCS patients include elevated HGB, atrial fibrillation and family history of coronary heart disease. Atherosclerosis, endothelial dysfunction and inflammation are linked to the development of CSF in bibliometric study.