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Received:June 12, 2022 Published Online:April 20, 2023
Received:June 12, 2022 Published Online:April 20, 2023
中文摘要: 目的 探讨高龄女性髋部骨折术后谵妄（POD）患者血清25-羟维生素D浓度及其临床意义。
方法 选择2019年1月至2022年5月在徐州医科大学附属邳州医院骨科行髋部骨折手术治疗后发生POD的32例高龄女性患者为POD组,使用记忆谵妄评定量表（MDAS）评估谵妄的严重程度。另选取髋部骨折手术后未发生POD的高龄女性患者32例作为对照组。采用双抗体夹心酶联免疫吸附法（ELISA）检测血清25-羟维生素D水平,分析其与谵妄程度的相关性。
结果 POD组患者血清25-羟维生素D水平［（15.79±1.71）ng/mL］明显低于对照组［（31.40±2.91）ng/mL］,差异有统计学意义（P＜0.05）。25-羟维生素D与MDAS评分呈负相关（r=-0.803,P＜0.01）。
结论 25-羟维生素D降低是高龄女性髋部骨折术后POD的危险因素,其血清浓度与谵妄程度负相关。高龄女性髋部骨折术前应检测血清25-羟维生素D浓度、补充维生素D,以预防POD的发生。
Abstract:Objective To investigate the serum 25-hydroxyvitamin D ［25-（OH）D］ concentration and its clinical significance in elderly women with postoperative delirium（POD） after hip fracture surgery.
Methods From January 2019 to May 2022, 32 elderly female patients who developed POD after hip fracture surgery in Pizhou Hospital Affiliated to Xuzhou Medical University were selected as POD group, for whom the memorial delirium assessment scale（MDAS） was used to assess the severity of POD. At the same time, 32 elderly female patients without POD after hip fracture surgery were served as controls. By double-antibody sandwich enzyme-linked immunosorbent assay（ELISA）, the levels of 25-（OH）D in two groups were detected. The correlation between the serum 25-（OH）D level and the degree of POD was analyzed.
Results The serum level of 25-（OH）D in POD group was significantly lower than that in control group ［（15.79±1.71）ng/mL vs（31.40±2.91）ng/mL, P＜0.05］, and the level of 25-（OH）D was negatively correlated with MDAS score（r=-0.803, P＜0.01）.
Conclusion The low level of 25-（OH）D is a risk factor for POD in elderly women with hip fracture surgery, and the preoperative detection of serum 25-（OH）D concentration and vitamin D supplementation are effective in preventing POD of the patients.
文章编号： 中图分类号：R619 文献标志码：B
基金项目:中国博士后科学基金面上项目（2020M681739）;江苏省卫健委医学科研项目（LKM2022048;Z2021221）;江苏省重点实验室开放课题（XZSYSKF2020004）;徐州医科大学校级科研课题（2018KJ23）
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