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Received:March 28, 2022 Published Online:January 20, 2023
Received:March 28, 2022 Published Online:January 20, 2023
中文摘要: 目的观察乌梅丸联合穴位埋线治疗寒热错杂证溃疡性结肠炎（UC）的临床疗效。
方法选择2019年1月至2021年12月于咸阳市中心医院就诊的98例寒热错杂证UC患者，随机分为中医治疗组33例、中西医结合组34例、对照组31例。对照组给予美沙拉嗪口服，中医治疗组给予乌梅丸联合穴位埋线治疗，中西医结合组给予美沙拉嗪、乌梅丸口服，联合穴位埋线治疗，疗程均为3个月。观察三组患者中医证候疗效、结肠黏膜损伤程度、炎症因子水平。
结果疗程结束后评价，对照组（70.97%）、中医治疗组（84.85%）、中西医结合组（91.18%）的总有效率依次提高，但差异无统计学意义（P＞0.05）。治疗后三组UCEIS评分及Geboes评分均较治疗前显著降低（P＜0.05），且中西医结合组优于中医治疗组（P＜0.05）及对照组（P＜0.01），中医治疗组优于对照组（P＜0.01）。治疗后三组患者血清C反应蛋白、肿瘤坏死因子-α和白细胞介素-6水平均显著降低（P＜0.05），且中西医结合组低于中医治疗组（P＜0.05）及对照组（P＜0.01），中医治疗组低于对照组（P＜0.01）。三组患者均未发生严重不良反应。
结论乌梅丸联合穴位埋线能够降低UC患者的炎症反应程度，促进结肠黏膜损伤的修复。中西医结合治疗UC的临床疗效能否获得有统计学意义的提高，有待扩大样本量进一步研究。
Abstract:ObjectiveToobservetheclinicalefficacyofWumeiPillcombinedwithacupointcatgutembeddinginthetreatmentofulcerativecolitis（UC）withcold-heatcomplicatedsyndrome.
MethodsNinety-eightpatientswithUCofcold-heatcomplicatedsyndromewhovisitedXianyangCentralHospitalfromJanuary2019toDecember2021wererandomlydividedintoTCMtreatmentgroup（treatedwithWumeiPillscombinedwithacupointcatgutembedding,TCMgroup,n=33）,integratedTCMandWesternmedicinegroup（givenoralMeisalqinandWumeiPillscombinedwithacupointcatgutembedding,combinedgroup,n=34）andcontrolgroup（withoralmeisalqin,n=31）.Afterthetreatmentfor3months,theTCMsyndromeefficacy,thedamagedegreeofcolonmucosaandthelevelofinflammatoryfactorswereobservedinthethreegroups.
ResultsAftertheendoftreatment,thetotaleffectiverateincreasedintheorderofcontrolgroup(70.97%),TCMtreatmentgroup(84.85%)andcombinedgroup(91.18%),butthedifferencewasnotstatisticallysignificant(P＞0.05).Aftertreatment,ulcerativecolitisendoscopicindexofseverity（UCEIS）scoreandGeboesscoresignificantlydecreasedinthreegroupscomparedwiththosebeforetreatment（P＜0.05）,andthoseincombinedgroupweresuperiortoTCMtreatmentgroup（P＜0.05）andcontrolgroup（P＜0.01）.TheserumlevelsofCRP,TNF-αandIL-6weresignificantlylowerthanthosebeforetreatmentinthreegroups（P＜0.05）andwerethelowestincombinedgroup,followedbyTCMtreatmentgroup（P＜0.05）andcontrolgroup（P＜0.01）.Therewerenoseriousadversereactionsinthethreegroups.
ConclusionInthetreatmentofUCpatients,WumeiPillcombinedwithacupointcatgutembeddingcanreducethedegreeofinflammationandpromotetherepairofcolonmucosadamage.WhethertheclinicalefficacyofintegratedTCMandwesternmedicineinthetreatmentofUCcanbeimprovedstatisticallyneedstobefurtherstudiedbyexpandingthesamplesize.
keywords: Ulcerativecolitis Cold-heatcomplicatedsyndrome Acupointcatgutembedding WumeiPills Meisalqin
文章编号： 中图分类号：R259 文献标志码：B
基金项目:
| Author Name | Affiliation |
| LUXiao-jun,GAOLi | DepartmentofGeriatrics，XianyangCentralHospital,Xianyang,Shaanxi712000,China |
| Author Name | Affiliation |
| LUXiao-jun,GAOLi | DepartmentofGeriatrics，XianyangCentralHospital,Xianyang,Shaanxi712000,China |
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