Abstract:Objective To analyze the effect of multimodal nonpharmacological interventions on glucocorticoid in the treatment of nonspecific interstitial pneumonia(NSIP), depression and quality of life. Methods One hundred and twenty patients with NSIP treated in Nanjing Drum Tower Hospital from April 2021 to December 2021 were selected, and randomly divided into test group and control group with 60 patients in each group. The control group was treated with glucocorticoid, and the test group was treated with multimodal nonpharmacological interventions on the basis of the control group. The changes of depression,quality of life were compared between the two groups. Results The total effective rate, quality of life scores of the test group were higher than those of the control group ,with a statistically significant difference (93.33% vs 78.33%, P＜0.05). The disappearance time of cough, fever and lung moist rale in the test group was shorter than that in the control group (P＜0.05). After intervention, the self depression scale score of the test group was lower than that of the control group, and the quality of life score was higher than that of the control group, with statistically significant differences (P＜0.01). Conclusion Multimodal nonpharmacological interventions applied to glucocorticoid in the treatment of NSIP can effectively ameliorate the clinical symptoms and depression, effectively strengthen the pulmonary function and improve the quality of life of patients.