Abstract:Objective To investigate the changes and clinical significance of urinary neutrophil gelatinase associated lipid transporter (NGAL) in patients with coronary heart disease and chronic heart failure. Methods One hundred and sixty-three patients with coronary heart disease and chronic heart failure admitted from Nanjing Jiangbei Hospital from 2017 to 2018 were selected as observation objects. In addition, 50 healthy people from 2017 to 2018 were selected as the control group. All subjects collected morning urine and determined NGAL content by colloidal gold method. The changes of urinary NGAL content and cardiac function indexes were compared between the two groups, and the changes of urinary NGAL content and cardiac function indexes were compared between different concentric function grades. The correlation between urinary NGAL and cardiac function indexes were analyzed. Results Urine NGAL and LVEDD in the study group were higher than those in the control group, while LVEF was lower than those in the control group, with significant difference(P＜0.05). The urine NGAL content and LVEDD in grade Ⅳ group were higher than those in grade Ⅲ and grade Ⅱ groups, and LVEF was lower than those in grade Ⅲ and grade Ⅱ groups(P＜0.05). The urine NGAL content and LVEDD in grade Ⅲ group were higher than those in grade Ⅱ group, and LVEF was lower than those in Grade Ⅱ group, with significant difference(P＜0.05). NGAL was negatively correlated with LVEF and positively correlated with LVEDD(P＜0.05). Conclusion The level of NGAL in urine of patients with chronic heart failure caused by coronary heart disease is significantly increased, and the increase is more obvious with the aggravation of the disease. It can be used as an auxiliary indicator to judge the condition of patients with chronic heart failure.