Abstract:ObjectiveTo systematically evaluate the myocardial protective effect of HTK solution and Del Nido solution in cardiac surgery. Methods The relevant literatures on the direct comparison of HTK solution (HTK group) and Del Nido solution (DN group) on myocardial protection in cardiac surgery were searched in the database of the Cochrane Library, PubMed, Embase, Wanfang, CBM, CNKI, and VIPthrough a computer, and data was merged and analyzed by RevMan 5.3 software. Results A total of 8 relevant studies were included. The total amount of cardioplegia in the HTK grouPwas significantly higher than that in the DN grouP( MD =147.92, 95% CI ：62.52-233.32, P<0.01), while the amount of blood transfusion in the DN grouPwas significantly higher than that in the HTK grouP( MD =-33.07, 95% CI ： -58.89--6.25, P=0.02). However, there was not significantly different in the cardiopulmonary bypass time, aortic occlusion time, postoperative mechanical ventilation time, ICU stay time, total hospital stay time, postoperative left ventricular ejection fraction, incidence of atrial fibrillation, and myocardial enzyme spectrum levels at 24 h after operation between the two groups (P>0.05). Conclusion In cardiac surgery patients, HTK and DN have equivalent protective effects on myocardium and have similar clinical effects.