Abstract:Objective To explore the levels of serum acetylcholine receptor antibody (AchRAb) and complement and its diagnostic value in children with myasthenia gravis. Methods Eighty myasthenia gravis children treated from May 2011 to July 2019 were selected as case group,and 80 healthy children undergoing physical examination in the same period were served as control group.The levels of serum AChRab,complement 3（C3） and peripheral blood T lymphocyte subsets ［CD4⁺(%) and CD8⁺(%)］were detected,and quantitative myasthenia gravis score (QMGS) was recorded and analyzed to observe their relationship. Results The serum levels of AchRAb,IFN-γ and TNF-α in case group were statistically higher than those in control group,and C3 content was lower than that in control group (all P<0.01).Compared with control group,CD4⁺T cells increased,and CD8⁺T cells decreased in case group (P<0.05,P<0.01).In case group,QMGS was 18 to 31 (24.19±2.18) points.Pearson correlation analysis showed that QMGS was positively correlated with Osserman classification,disease course and levels of AChRab,IFN-γ,TNF-α,C3 and CD4⁺T cell in myasthenia gravis children respectively(all P<0.01).Logistic regression analysis showed that AChRab,IFN-γ and C3 were the independent factors influencing QMGS in children with myasthenia gravis (P<0.05,P<0.01). ConclusionsThe abnormal levels of serum AchRAb and C3 are abnormally high in myasthenia gravis children,which are closely related to the patient′s condition.AchRAb,IFN-Υ,and C3 are the important factors influencing myasthenia gravis children.