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Received:December 25, 2019 Published Online:September 20, 2020
Received:December 25, 2019 Published Online:September 20, 2020
中文摘要: 目的 探讨外周血中性粒细胞/淋巴细胞比值(NLR)对脓毒症患者预后的评估价值。方法 入选2015年5月至2019年10月脓毒症患者138例,根据随访28 d生存情况分为死亡组(48人)及存活组(90人),比较两组APACHE Ⅱ评分、NLR等参数的差异,绘制受试者工作特征(ROC)曲线,评价NLR对预后的预测价值。结果 脓毒症患者28 d总死亡率为34.78 %,其中不同预后组APACHE Ⅱ评分、入选24 h的NLR(NLR-1)等组间差异有统计学意义(P<0.05)。ROC曲线提示 NLR-1曲线下面积(AUC)为0.913,高于APACHE-Ⅱ评分的0.827。以 NLR>17.5作为预测28 d死亡风险的临界值,敏感度为87.5%,特异度为81.1%。结论 高NLR与脓毒症患者的死亡密切相关,对于NLR高的患者应予以高度重视。
中文关键词: 脓毒症 预后 中性粒细胞/淋巴细胞比值 APACHE Ⅱ
Abstract:Objective To explore the value of neutrophil to lymphocyte ratio(NLR) in predicting the prognosis of patient with sepsis. Methods A total of 115 septic patients treated from May 2015 to October 2019 were divided into death group (n=48) and survival group(n=90) according to the 28- day survival.APACHEⅡ score and NLR were compared between two groups, and ROC curve was plotted for assessing the prognostic evaluation of NLR. Results The 28-day mortality rate was 34.78%.There were significant differences in APACHE Ⅱ score and 24-hour NLR(NLR-1) after entering ICU between two groups (all P<0.05).ROC curve showed that the area under NLR-1 curve (AUC) was 0.913, which was higher than that of APACHE-II score (0.827).Based on NLR>17.5 as a predictor of cut-off value of death in 28 days.The sensitivity and specificity were 87.5% and 81.1%, respectively. Conclusion High NLR is closely related to the death of patients with sepsis, so attention should be payed to the septic patients with a higher NLR.
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基金项目:河北省医学科学研究重点课题计划项目(20180787，20180788)
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