Abstract:ObjectiveTo analyze the impacts of cardiac function classification and pulmonary arterial hypertension (PAH) on the postoperative complications of patients with rheumatic heart disease (RHD) underwent valve replacement operation.MethodsA retrospective study was conducted on the clinical data of 200 patients with RHD receiving valve replacement from March 2016 to March 2019.After screening the possible risk factors of postoperative complications by Pearson correlation analysis,multivariate Logistic regression analysis was used to analyze the independent risk factors of complications after valve replacement operation.ResultsThere were 16 patients (8.00%) with postoperative complications,including 1 case (0.50%) of cerebrovascular accident,3 cases (1.50%) of pulmonary infection,4 cases (2.00%) of low cardiac output,3 cases (1.50%) of renal insufficiency and 5 cases (2.50%) of deaths.Monofactor analysis showed that age,New York Heart Association (NYHA) classification of cardiac function,tricuspid insufficiency,diabetes mellitus,cardiopulmonary bypass time,aortic cross clamp time and PAH were closely related to the occurrence of postoperative complications in RHD patients (P<0.05,P<0.01).Multivariate Logistic regression analysis showed that diabetes mellitus,NYHA classification,cardiopulmonary bypass time and PAH were the independent influencing factors of complications after valve replacement in RHD patients (P<0.05,P<0.01).ConclusionDiabetes mellitus,PAH,high NYHA classification (Ⅲ~Ⅳ) and prolonged cardiopulmonary bypass(>180 min) are the independent risk factors for complications after valve replacement surgery in patients with RHD.