Abstract:Objective To explore the expression of autophagy-related proteins p62 and Beclin1 in cervical cancer tissues and their significance. Methods From January 2016 to December 2018,120 cases of cervical cancer tissues,50 cases of cervical tissues of non-cancerous uterine myoma and 50 cases of cervical intraepithelial neoplasia (CIN Ⅲ) tissues obtained by surgical resection were selected as the study objects. The expression levels of p62 and Beclin1 in three kinds of tissues were detected,respectively,and the correlation was analyzed between them. Results p62 was mainly expressed in the cell nucleus of cervical squamous carcinoma cells and CIN Ⅲ tissues with yellowish-brown staining.Beclin 1 was mainly expressed in the cytoplasm and the membrane of normal cervical epithelium and CIN Ⅲ cells with yello-brown staining.The positive expression of p62 in cervical squamous carcinoma cells was significantly higher than that in normal cervical epithelium and CIN Ⅲ tissues (P<0.017),while the positive expression of Beclin 1 was significantly lower than that in normal cervical epithelium and CIN Ⅲ tissues (P<0.017),respectively.The expression of p62 in patients with lymph node metastasis was higher than that in patients without lymph node metastasis (P<0.05).The expressions of p62 and Beclin 1 were not related to other clinical features of patients (P>0.05). ConclusionThe expression levels of autophagy-related proteins p62 and Beclin1 are associated with the occurrence and progression of cervical cancer,and p62 expression is associated with the prognosis of cervical cancer.Both p62 and Beclin1 may be used to evaluate the occurrence and development of cancer.