Abstract:Objective To investigate the clinical effect of clarithromycin combined with ambroxal(mucosolvan) in the treatment of adult acute paranasal sinusitis. Methods A total of 142 patients with nasosinusitis who received treatment from January 2016 to January 2017 were selected and divided into control group and study group according to treatment method (n=71,each).The control group was treated with clarithromycin,while the study group was treated with clarithromycin combined with mucosolvan.The nasal mucociliary clearance rate (MCR),nasal mucociliary transport rate (MTR) and clinical efficacy were compared between the two groups. Results At 3 d and 7 d after the treatment,MCR and MTR in the study group were significantly better than that in the control group (all P<0.05).The total effective rate in study group was significantly better than that in control group (91.5% vs 78.8%,P<0.05). Conclusion The application of Clarithromycin combined with Mucosolvan in the treatment of adult acute paranasal sinusitis can significantly improve the scores of MCC and MTR,and the clinical effect is good.