Abstract:Objective To explore the effects of minimally invasive gallbladder-preserving lithotomy with laparoscopy and choledochoscopy on gastrointestinal function, serum leptin and endothelin in patients with gallstone. Methods A total of 87 patients with gallbladder stone treated from June 2016 to October 2017 were selected and divided into observation group (n=47) and control group(n=40) according to different surgical methods. The laparoscopic cholecystectomy was performed in control group, and laparoscopy combined with choledochoscopy for minimally invasive gallbladder-preserving lithotomy was performed in observation group. The intraoperative and postoperative conditions, gastrointestinal function, serum levels of leptin and endothelin and postoperative complications were compared between two groups. Results Intraoperative blood loss[(16.53±2.72)ml vs (24.75±4.53)ml] in observation group was significantly lower than that in control group, but operation time [(75.32±12.05)min vs (53.21±8.15)min] was significantly longer than that in control group (all P<0.05). The recovery time of normal diet[(1.03±0.26)d vs (1.55±0.46)d], bowel sounds[(0.75±0.12)d vs (0.98±0.13)d], anal exhaust time[(1.25±0.17)d vs (1.88±0.46)d] and the incidence of gastrointestinal adverse reactions (29.79% vs 57.50%) in observation group were statistically lower than those in control group (all P< 0.05). The motilin and gastrin levels after operation were significantly lower than those before operation in both two groups and were significantly lower in control group than those in observation group respectively [(178.23±18.14)pg/ml vs (201.21±19.05)pg/ml, (115.05±10.79)pg/ml vs (127.36±8.23) pg/ml, all P<0.05]. Serum leptin level in observation group decreased significantly after operation(P<0.05), but there was no significant change in it before and after operation in control group (P>0.05). There was no statistical difference in serum leptin level between two groups (P>0.05). After operation, endothelin level was significantly higher than that before operation in both two groups and was statistically higher in control group than that in observation group (P<0.05). There was no significant difference in total incidence of complications between two groups (P>0.05). Conclusion Laparoscopy combined with choledochoscopy for minimally invasive gallbladder preserving lithotomy can effectively reduce serum leptin level and relieve stress reaction of the body. It has less influence on gastrointestinal function.