Abstract:Objective To investigate the use condition of thrombus pre-aspiration in emergency intervention therapy for the occlusion of left coronary artery in patients with acute myocardial and compare with traditional balloon pre-dilatationto. Methods Fifty acute ST segment elevation myocardial infarction (STEMI) patients with acute occlusion of left coronary artery who admitted in Yuebei People Hospital and underwent emergency intervention therapy from 2015 to 2017 were selected. The patients were randomly divided into two groups (n=25 each):thrombus pre-aspiration group [thrombus pre-aspiration was given before percutaneous coronary intervention (PCI)] and balloon pre-dilatation group (conventional balloon pre-dilatation was given before PCI). The effect of the two methods of interventional therapy was compared. Results Fifty patients were successfully rescued by emergency intervention procedure. The coronary recanalization rate was 100%, and the survival rate after operation was 100%. The procedure time needed from performing balloon pre-dilatation or thrombus pre-aspirationartery after coronary angiography to restoring the blood flow of coronary artery in balloon pre-dilatation group was slightly less than that in thrombus pre-aspiration group, but there was no significant difference between two groups [(12.8±4.2)min vs (13.2±4.3)min, P＞0.05]. X ray exposure dose in thrombus pre-aspiration group was significantly less than that in balloon pre-dilatation group [(276.0±37.0)mGy vs (369.0±47.0)mGy, P＜0.05]. Total operative time in thrombus pre-aspiration group was significantly less than that in balloon pre-dilatation group [(18.3±3.2) min vs (23.8±4.5)min, P＜0.05]. Corrected TIMI (thrombolysis in myocardial infarction) frame count (CTFC) in thrombus pre-aspiration group was significantly less than that in balloon pre-dilatation group [(28.7±11.5) frame/s vs (37.5±13.7) frame/s, P＜0.05]. Remission rate of angina pectoris at 30-min after operation in thrombus pre-aspiration group was significantly higher than that in balloon pre-dilatation group(96.0% vs 68.0%, P＜0. 05). There was no significant difference in ST-segment complete resolution rate 30-min after operation between two groups (P>0.05). There were no significantly differences in major adverse cardiovascular events (MACE) at 1-week, 3-month and 12-month after operation between two groups(all P>0.05). Conclusion Thethrombus pre-aspiration in emergency intervention therapy contributes to the improvement of blood flow re-perfusion after PCI, the reduction of X ray exposure time, the improvement of patients' prognosis and the reduction of intraoperative complications in patients with acute occlusion of left coronary artery.