Abstract:Objective To investigate the effect of percutaneous vertebroplasty with high viscosity bone cement in the treatment of osteoporotic lumbar fracture and the improvement of biochemical indexes of bone metabolism.? Methods total of 90 patients with osteoporotic lumbar fractures from July 2015 to July 2016 were divided into observation group and control group according to random number table method (n=45, each). Percutaneous vertebroplasty with high viscosity bone cement was performed in observation group, and conventional treatment was performed in control group. The visual analogue score(VAS), Oswestry disability index (ODI) spine score, spinal vertebral height, bone cement leakage and postoperative complications were compared and analyzed between two groups.? Results After treatment, VAS score and ODI score decreased in both two groups and were significantly lower in observation group than those in control group (P<0.05); the anterior vertebral height, midline vertebral height and vertebral height significantly increased and was significantly higher in observation group than those in control group (P<0.05); the bone cement leakage(13. 33% vs 31. 11%) and complication rate(11.11% vs 31.11%) in observation group were significantly lower than those in control group (χ²=4.1143, 5.4040, P<0.05).? Conclusion Percutaneous vertebroplasty with high viscosity bone cement can effectively improve the vertebral height and predict the risk of lumbar fracturein patients with osteoporotic lumbar fracture.